De La Salle College was an independent Roman Catholic comprehensive single-sex secondary day school for boys, located in Ashfield, an inner-western suburb of Sydney, New South Wales, Australia.

Established in 1916 by the De La Salle Brothers and Vincentian Fathers, the college caters to students in Year 7 to Year 12 from the inner-west Parishes of the Archdiocese of Sydney. The college is under the patronage of the Archbishop of Sydney, Anthony Fisher. De La Salle College is one of 18 Lasallian Schools in Australia, and in the 1970s became the first Catholic high school in Australia to have a lay headmaster.

On 8 June 2022, it was announced that the college would amalgamate with adjacent girls' high school, Bethlehem College, and St Vincent’s Primary School, due to increasing demand for co-educational schools in inner Sydney. From 2023, the new school was known as St Vincent's College and from 2027, after a five year transition period, it will become a fully K-12 co-educational school precinct.

The school is affiliated with the Catholic Secondary Schools Association NSW/ACT, and the Metropolitan Catholic Colleges Sports Association (MCC).

In education, the college was fully accredited in 2018 to run the Newman Selective Gifted Education Program (the Gifted and Talented program), which caters towards the significant learning needs of capable students. The program is currently being facilitated in a number of the Catholic Primary and Secondary Schools within Sydney Catholic Schools. The school also uses Inquiry-Based Learning approach, focusing mainly on the Solution Fluency framework. They offer a number of co-curricular activities and experiences, including immersions to Lasallian schools overseas. The school follows the NSW Syllabus and Australian Curriculum.